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Table 2 Responsiveness (standardized response mean SRM and number of individuals with changes exceeding the measurement noise # > SRD) and concurrent validity (correlation ρ to Nine Hole Peg Test NHPT and Box and Block Test BBT) for persons with MS

From: Influence of virtual reality and task complexity on digital health metrics assessing upper limb function

Metric

PPIT

VPIT

SRM

# > SRD

ρ BBT

ρ NHPT

SRM

# > SRD

ρ BBT

ρ NHPT

Log Jerk TP

− 0.32

5

− 0.84

0.68

− 0.46

1

− 0.56

0.63

Log Jerk RT

0.19

4

− 0.62

0.75

− 0.35*

0

− 0.58

0.67

SPARC RT

− 0.12

7

− 0.50

0.44

− 0.29

10

− 0.67

0.79

Path length ratio TP

0.02

5

− 0.14

0.27

− 0.13

7

− 0.45

0.32

Path length ratio RT

− 0.17

3

− 0.49

0.45

− 0.46*

7

− 0.49

0.32

Velocity max. RT

0.21

0

0.48

-0.65

0.16

3

0.53

− 0.56

Jerk peg approach

0.16*

8

− 0.50

0.67

− 0.43

10

− 0.38

0.28

Force rate num. peaks TP

− 0.44

2

− 0.57

0.52

− 0.53

5

− 0.42

0.44

Force rate SPARC TP

0.02

1

− 0.53

0.41

− 0.47*

1

− 0.34

0.50

Force rate SPARC hole approach

0.04

3

− 0.48

0.39

− 0.42*

8

− 0.57

0.47

Aggregate (abs. values)

0.16 ± 0.17

3.5 ± 3.0

0.50 ± 0.09

0.48 ± 0.27

0.43 ± 0.18

6.0 ± 7.0

0.51 ± 0.15

0.49 ± 0.31

  1. *Indicates metrics that had a statistically significant change over the rehabilitation program (1 for the PPIT, 4 for the VPIT). Aggregate indicates the median ± inter-quartile range of the absolute (abs.) value across metrics