Fig. 1

Simplified overview on preclinical applications of the four stimulation methods in the focus of this review: a Transcranial magnetic stimulation (TMS) uses magnetic fields to stimulate neurons in the brain non-invasively. b Transcranial direct current stimulation (tDCS) delivers low intensity electrical currents to the brain via scalp electrodes in order to modulate neural activity. c Deep brain stimulation (DBS) involves the implantation of a device that delivers electrical impulses to specific areas of the brain. d Vagus nerve stimulation (VNS) uses cuff electrodes to deliver electrical stimulation to the vagus nerve. Figure created with BioRender.com